Frequency and outcomes of extremely early preterm birth in pregnant women with new coronavirus infection COVID-19

The frequency of extremely early preterm birth (ERPR), their obstetric and perinatal outcomes, morphological features of the placenta in pregnant women in the city of Chelyabinsk and the Chelyabinsk region (CO) with a new coronavirus infection (NCI) in periods 1-2 and 3-4 waves of the COVID pandemic were studied. -19. The results obtained indicate that there is no increase in the frequency of ERPR in pregnant women with NCI. Delivery by caesarean section is associated mainly with the increase in acute respiratory distress syndrome (ARDS) of the mother. In the period of waves 3-4 of the COVID-19 pandemic, an increase in the perinatal mortality rate was noted compared to the period of waves 1-2 without statistical significance of these indicators. At the same time, antenatal fetal death during the 3rd-4th wave of the NCI pandemic was observed statistically significantly more often (p=0.033). The features of placental damage to the placentas in patients with NCI with ERPR and antenatal fetal death during the 3rd-4th wave of the pandemic are severe maternal and fetal vascular malperfusion and severe acute inflammatory lesions of the placenta (2,3 stages and 2,3 degrees).

New Coronavirus Infection Covid-19 and Women's Reproductive Health. Facts and Assumptions

The review presents data on the possible ways in which the SARS-CoV-2 and COVID-19 virus affects the female reproductive system and the already recorded negative consequences. Recommendations on pregnancy planning and the specifics of using hormonal contraceptive methods, as well as approaches to specific prevention of a new coronavirus infection from the standpoint of safety and preserving the reproductive health of women during the COVID-19 pandemic are outlined.

Favorable outcome of the extremely severe course of the new coronavirus infection covid-19 during pregnancy in the presence of overall lung damage, acute myocarditis, and myocardial infarction

Background: The new coronavirus infection (NCI) COVID-19 in pregnant women occurs in various types from asymptomatic to extremely severe ones with the development of multiple organ failure and sepsis. SARS-CoV-2 infection occurs at the cellular level through viral binding to angiotensin-converting enzyme 2 (ACE2) receptors, the presence of which in the myocardium and vascular endothelial cells explains the mechanism of severe cardiovascular complications of NCI. The development of the latter has been demonstrated in few studies, whereas favorable outcomes for the mother and fetus in the presence of overall lung damage and acute coronary syndrome have not been reflected in the literature. Case report: The article describes and analyzes the favorable outcome of extremely severe NCI Covid-19 in a pregnant woman with overall lung damage, the development of acute myocarditis and myocardial infarction in the postpartum period. Conclusion: The timely referral of a pregnant woman with extremely severe NCI COVID-19 to the obstetric hospital of an infectious diseases hospital for patients with NCI COVID-19 for specialized medical care using a multidisciplinary approach, as well as the consideration of possible cardiac complications in this disease, their timely diagnosis and correction made it possible to effectively prevent an unfavorable outcome for the mother and fetus. © 2021, Bionika Media Ltd.. All rights reserved.